R1336mzz(E) trans-1,1,1,4,4,4-hexafluoro-2-butene Refrigerant · Safety Data Sheet (SDS)

1.1 Product identifier

1.2 Details of the supplier of the safety data sheet

1.3 Emergency telephone number

National Chemical Emergency Hotline (China): +86-532-83889090 (24 hours)

Zhejiang Province Chemical Emergency Consultation: +86-571-88071797

Supplier Emergency Contact: +86 551 6558 9290

2.1 GHS classification

2.2 GHS label elements

Signal word: Warning

2.3 Other hazards

• Vapor is heavier than air and may spread long distances along the ground, creating an oxygen-deficient environment in low-lying areas.
• Non-flammable, but decomposes at high temperatures (>500°C) producing toxic and corrosive gases (hydrogen fluoride, carbon monoxide, carbonyl fluoride, etc.).
• Cylinders may rupture or burst when heated due to increased internal pressure.
• Harmful to aquatic life; avoid release to the aquatic environment.

3.1 Substance/mixture

This product is a pure substance (trans isomer).

3.2 Composition information

3.3 Impurity information

4.1 Description of necessary first aid measures

General advice: Remove victim from contaminated area immediately. Keep warm and at rest. Show this SDS to attending physician.

Inhalation:

• Move victim to fresh air immediately. Keep airway clear.
• Administer oxygen if breathing is difficult.
• If not breathing, give artificial respiration (preferably with bag-valve-mask or pocket mask; avoid mouth-to-mouth).
• If no pulse, start cardiopulmonary resuscitation (CPR) immediately.
• Keep victim warm and at rest. Monitor condition closely.
• Seek medical attention immediately.

Skin contact (frostbite):

• Immediately flush affected area with large amounts of lukewarm water (37–40°C) to promote rewarming.
• Do NOT use hot water (>40°C) or direct heat (e.g., electric heaters).
• Do NOT rub or massage frostbitten area; this may worsen tissue damage.
• Carefully remove frozen clothing. If clothing sticks to skin, do NOT pull it off; cut around it.
• Cover with sterile dressing.
• Seek medical attention immediately.

Eye contact:

• Immediately hold eyelids open and rinse thoroughly with plenty of water or normal saline for at least 15 minutes.
• Ensure complete irrigation of all eye surfaces by lifting upper and lower lids.
• Remove contact lenses if present and easily removable.
• Seek medical attention immediately, preferably from an ophthalmologist.

Ingestion:

Not applicable. This substance is a liquid at ambient temperature but ingestion exposure is unlikely. If liquid is accidentally swallowed, do NOT induce vomiting; seek medical attention immediately.

4.2 Most important symptoms and effects, both acute and delayed

• Acute inhalation: dizziness, drowsiness, headache, nausea, ataxia, loss of consciousness, cardiac arrhythmia.
• Skin contact (liquid): frostbite (pale, hard skin, pain, blistering).
• Eye contact (liquid): severe frostbite, corneal damage, visual impairment.

4.3 Indication of any immediate medical attention and special treatment needed

5.1 Extinguishing media

Suitable extinguishing media: This substance is non-flammable. Use extinguishing agent appropriate for surrounding fire. Carbon dioxide, dry chemical, water fog, and foam are acceptable.

Unsuitable extinguishing media: No specific contraindications.

5.2 Special hazards arising from the substance or mixture

• Non-flammable. No flash point. No explosive limits.
• Thermal decomposition at high temperatures (>500°C) produces toxic and corrosive gases: hydrogen fluoride, carbon monoxide, carbonyl fluoride, etc.
• Cylinders may rupture or burst when heated due to increased internal pressure.
• May react with alkali metals, alkaline earth metals, and aluminum powder under certain conditions.

5.3 Hazardous combustion products

Hydrogen fluoride (HF), carbon monoxide (CO), carbonyl fluoride (COF₂), and other fluorinated compounds.

5.4 Advice for firefighters

• Firefighters must wear positive-pressure self-contained breathing apparatus (SCBA) and full protective fire-resistant clothing.
• If possible, move containers from fire area to a safe location.
• Cool containers with water spray from a safe distance until fire is extinguished.
• Immediately evacuate if containers show discoloration or if pressure relief devices begin to vent.
• Isolate the area; keep unauthorized personnel out.
• Avoid direct water spray on leaking liquefied gas, as this will accelerate evaporation and dispersion.
• Firefighting runoff water must NOT be discharged to waterways (harmful to aquatic life); collect and treat separately.

6.1 Personal precautions, protective equipment and emergency procedures

• Evacuate personnel from the leak area to upwind locations immediately. Establish a perimeter and restrict access.
• Emergency responders should wear SCBA, standard work clothing, cryogenic gloves, and eye protection.
• Enter from upwind direction.
• Stop leak if it can be done safely.
• Do not touch or walk through spilled material.
• Maintain emergency contact personnel for external support.

6.2 Environmental precautions

• Prevent liquid/gas from entering sewers, basements, or confined spaces.
• This substance is harmful to aquatic life; prevent spilled material from entering rivers, lakes, oceans, or other water bodies.
• Ventilate the area to accelerate gas dispersion; use inert absorbent material for liquid spills.
• Minimize releases to control greenhouse gas emissions; recover whenever possible.
• Avoid release to atmosphere, waterways, and soil.

6.3 Methods and materials for containment and cleaning up

• Small leak: Increase ventilation to accelerate gas dispersion. Monitor oxygen levels to prevent asphyxiation. For liquid leaks, use inert absorbent material (e.g., vermiculite, sand) for containment.
• Large leak:
  • Close source valve if safe to do so.
  • Recover using dedicated gas recovery equipment.
  • If recovery is not possible, use water fog/mist to dilute and dissolve gas. Note: fluorinated wastewater must be collected and treated; do NOT discharge to waterways.
  • If cylinder valve cannot be closed, immerse cylinder in alkaline water solution for absorption.
• Cylinder leak: Move cylinder to a well-ventilated safe area and vent slowly. If valve cannot be closed, contact supplier for professional handling.

6.4 Reference

See Section 8 (Exposure controls/personal protection) and Section 13 (Disposal considerations).

7.1 Precautions for safe handling

• Handle in closed systems with adequate natural ventilation or local exhaust.
• Personnel must be specially trained and strictly follow operating procedures. Certified personnel only.
• Prevent gas/liquid leakage into workplace atmosphere.
• Avoid contact with reactive metals and strong oxidizing agents.
• Handle cylinders carefully; do not drop, slide, roll, or bump cylinders. Use proper lifting equipment.
• Equip area with leak emergency response equipment.
• No smoking, eating, or drinking in work areas.
• Wear insulated gloves and eye/face protection when handling liquid to prevent frostbite.
• Use explosion-proof ventilation systems and equipment.
• Periodically inspect cylinders, valves, and piping for leaks.
• Avoid release to the environment; take special care to prevent water pollution.

7.2 Conditions for safe storage, including any incompatibilities

• Store in a cool, dry, well-ventilated non-flammable gas warehouse.
• Storage temperature should not exceed 45°C. Keep away from fire, heat sources, and direct sunlight.
• Store separately from oxidizers and reactive metals. Do not co-store with incompatible materials.
• Storage area should be equipped with leak emergency response equipment.
• Cylinders must be stored upright with valve caps and safety rings in place, properly secured to prevent falling.
• Use explosion-proof lighting and ventilation systems.
• Prohibit use of equipment and tools that can generate sparks.
• Filling coefficient must not exceed 1.1 kg/L.
• Post clear safety warning signs in storage areas.
• Implement two-person receiving/issuing and two-person custody system.

7.3 Specific end uses

For industrial use only. Personnel must be professionally trained. Do not use for direct food contact, medical inhalation, or other unapproved applications.

8.1 Control parameters

Note: Per GBZ 2.1-2019 (Occupational exposure limits for hazardous agents in the workplace — Part 1: Chemical agents), this substance is not currently listed in the Chinese OEL table. International standards and manufacturer recommendations are advised during operation. NOAEL is 30,000 ppm.

8.2 Exposure monitoring methods

Gas chromatography with flame ionization detection (GC-FID) or mass spectrometry (GC-MS); infrared gas analyzer.

8.3 Appropriate engineering controls

• Enclosed process design with general ventilation or local exhaust.
• Provide safety shower and eyewash station.
• Install gas detection alarms in areas where large leaks may occur.
• Use explosion-proof electrical equipment.

8.4 Individual protection measures

Respiratory protection:

• Normal conditions (below exposure limit): no special protection required.
• Elevated concentrations: half-face respirator with organic vapor/acid gas cartridge is recommended.
• High concentration or emergency rescue/evacuation: positive-pressure self-contained breathing apparatus (SCBA) must be worn.

Eye/face protection:

• General handling: no special protection required.
• When handling liquid or potential liquid exposure: chemical safety goggles or face shield must be worn to prevent frostbite.

Skin protection:

• Hand protection: general work gloves for normal handling; cryogenic-insulated gloves (e.g., dry ice gloves, leather cold gloves) for liquid contact.
• Body protection: standard work uniform; cold-resistant clothing for liquid contact.
• Other: no smoking in work areas; avoid high-concentration inhalation; use a buddy system when entering tanks, confined spaces, or other high-concentration areas.

8.5 Hygiene measures

• Remove contaminated clothing and wash skin thoroughly after work.
• Maintain good personal hygiene.
• Ensure eyewash and emergency shower are available in the workplace.

9.1 Basic physical and chemical properties

9.2 Thermodynamic properties

9.3 Other safety data

10.1 Reactivity

Chemically stable under normal temperature and pressure conditions; not readily reactive.

10.2 Chemical stability

Stable under normal conditions of temperature and pressure.

10.3 Possibility of hazardous reactions

• Thermal decomposition at high temperatures (>500°C) produces toxic hydrogen fluoride, carbon monoxide, and carbonyl fluoride.
• May react with alkali metals, alkaline earth metals, and aluminum powder under high temperature or specific conditions.
• May undergo oxidation-reduction reactions with strong oxidizing agents.

10.4 Conditions to avoid

High temperature, open flame, direct heat sources, cylinder overpressure

10.5 Incompatible materials

Reactive metals (sodium, potassium, calcium, aluminum powder, magnesium powder, etc.), strong oxidizing agents

10.6 Hazardous decomposition products

Hydrogen fluoride (HF), carbon monoxide (CO), carbonyl fluoride (COF₂), and other fluorinated compounds

10.7 Hazardous polymerization

Will not occur.

11.1 Acute toxicity

11.2 Skin irritation/corrosion

Liquid contact can cause frostbite (physical injury), but is not a chemical corrosive. GHS classification: no skin corrosion/irritation classification (physical frostbite only).

11.3 Eye irritation/corrosion

Liquid contact can cause severe frostbite and corneal damage. GHS classification: no eye damage/eye irritation classification (physical frostbite only).

11.4 Respiratory or skin sensitization

No sensitization reported. Available animal test data and human epidemiology data show no sensitization effect.

11.5 Germ cell mutagenicity

In vitro and in vivo tests (Ames test, chromosome aberration test, mouse micronucleus test, etc.) show no mutagenic effect.

11.6 Carcinogenicity

Insufficient evidence for carcinogenicity.

• IARC (International Agency for Research on Cancer): Not listed
• ACGIH (American Conference of Governmental Industrial Hygienists): Not listed
• EPA (U.S. Environmental Protection Agency): Not listed

11.7 Reproductive toxicity

Animal studies show no significant reproductive or developmental toxicity at high concentrations. No human reproductive toxicity data available.

11.8 STOT-single exposure

• Narcotic effect (Category 3): Inhalation of high concentrations may cause central nervous system depression, manifested as dizziness, drowsiness, headache, and impaired consciousness.
• Cardiac effects: High-concentration exposure may cause cardiac arrhythmia, especially under stress or exercise (catecholamine sensitization).

11.9 STOT-repeated exposure

Repeated low-concentration exposure shows no significant target organ toxicity. NOAEL (No Observed Adverse Effect Level) is 30,000 ppm. Long-term animal inhalation studies have not shown clear organ damage.

11.10 Aspiration hazard

Not expected to cause aspiration pneumonia in gaseous form. However, high-concentration inhalation can cause CNS depression and cardiac sensitization.

12.1 Ecotoxicity

Note: This substance is GHS-classified as hazardous to the aquatic environment - acute Category 3 (H412). Spills must be prevented from entering water bodies.

12.2 Persistence and degradability

• Atmospheric degradation: Primarily degraded by reaction with hydroxyl radicals; atmospheric lifetime ~6 days (very short).
• Biodegradability: Poorly biodegradable (not readily degraded by microorganisms).
• Hydrolysis: Not readily hydrolyzed at ambient temperature.
• Photodegradation: Can be photochemically degraded in the atmosphere.

12.3 Bioaccumulative potential

log P ≈ 3.5. Some bioaccumulation potential exists, but still below the bioconcentration threshold of log P = 4.5.

12.4 Mobility in soil

As a liquid, it has some volatility and low water solubility, resulting in relatively high mobility. When released to soil, a portion volatilizes to the atmosphere while the remainder is retained in the soil.

12.5 Results of PBT and vPvB assessment

Does not meet PBT (persistent, bioaccumulative, and toxic) / vPvB (very persistent, very bioaccumulative) criteria.

12.6 Other adverse effects

• Ozone Depletion Potential (ODP): 0 (no chlorine atoms; does not deplete the ozone layer at all; HFO-class non-ODS substance)
• Global Warming Potential (GWP, 100-year time horizon): 9 (relative to CO₂ = 1, ultra-low)
• Fourth-generation HFO eco-friendly refrigerant with GWP = 9; virtually no greenhouse effect.
• Not a controlled substance under the Montreal Protocol (ODP = 0); falls outside the scope of the Kigali Amendment (ultra-low GWP), enjoying favorable/exempt status.

13.1 Waste treatment methods

Product/residues:

• Do NOT release directly to atmosphere (greenhouse gas).
• Recovery and recycling (purification and reuse) is the preferred approach (recommended).
• If recovery is not feasible, dispose of through a licensed hazardous waste treatment facility.
• High-temperature incineration with alkaline scrubber for fluoride removal is an acceptable method.
• Do not discharge to sewers, waterways, or soil (harmful to aquatic life; prevent water pollution).

Contaminated packaging:

• Empty cylinders must be returned to supplier or a qualified facility for disposal. Do not discard or cut empty cylinders.
• Empty cylinders with residual pressure/liquid are managed as hazardous waste.

13.2 Special precautions for disposal

• Refer to national and local regulations before disposal (e.g., Solid Waste Pollution Prevention and Control Law, Hazardous Waste Storage Pollution Control Standards, etc.).
• Personnel should wear appropriate personal protective equipment (see Section 8).
• Ensure good ventilation to prevent asphyxiation.
• Disposal must be performed by a qualified and licensed facility.
• Disposal records should be maintained.
• Fluorinated wastewater/liquid must be collected and treated; do NOT discharge to waterways.

14.1 UN number

3163 ((E)-1,1,1,4,4,4-Hexafluoro-2-butene, liquefied gas, pressurized)

14.2 UN proper shipping name

(E)-1,1,1,4,4,4-HEXAFLUORO-2-BUTENE (HFO-1336mzz(E))

14.3 Transport hazard class(es)

Class 2.2 Non-flammable, non-toxic gas

14.4 Packing group

Not applicable (Class 2 gases are not assigned a packing group)

14.5 Packing mark / Hazard label

• Primary hazard label: Non-flammable non-toxic gas (green, Class 2.2)
• Subsidiary hazard label: None

14.6 Methods and materials for containment and packaging

• Seamless steel cylinders. Cylinders must comply with applicable national standards (e.g., GB 5099).
• Common package sizes: 50 kg, 100 kg, 400 kg, 800 kg cylinders; recyclable ISO tanks.
• Filling coefficient must not exceed 1.1 kg/L.
• Cylinder valve outlet thread direction: right-hand thread for non-flammable non-toxic gases.

14.7 Special requirements for different modes of transport

Road transport:

• Vehicles must have hazardous cargo transport license.
• Cylinders must have valve caps and safety rings in place.
• Cylinders generally laid flat with valves pointing in same direction; do not stack crosswise. Height must not exceed vehicle guardrail.
• Transport during early morning/evening in summer to avoid direct sunlight.
• Follow designated routes; do not stop in residential or densely populated areas.

Rail transport:

• Prohibit hump shunting (no free-roll classification).
• Transport in boxcars; cylinders upright or laid flat and secured.

Marine transport (IMDG Code):

• UN 3163, Class 2.2
• Marine pollutant: No (Note: GHS classification includes H412; impact on aquatic environment should be considered during marine transport)
• Stowage category: A (on deck or under deck)

Air transport (ICAO/IATA DGR):

• UN 3163, Class 2.2
• Non-flammable non-toxic gas
• Acceptable on passenger and cargo aircraft (subject to quantity limits)

14.8 Special precautions for user

• Do not co-transport with oxidizers, reactive metals, or food/feed products.
• Vehicles must be equipped with appropriate fire extinguishing equipment and leak emergency response gear.
• Transport personnel must be specially trained and certified.
• Protect from sunlight, rain, and high temperature during transit.
• When stopping en route, stay away from fire, heat sources, and high-temperature areas.
• Exhaust pipes of vehicles carrying this product must be fitted with spark arrestors.
• Load and unload carefully to prevent damage to cylinders and fittings.
• Prevent spilled material from contaminating water bodies (harmful to aquatic life).

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture

China regulations:

• Regulations on the Safe Management of Hazardous Chemicals (State Council Decree No. 591): Safety management of production, storage, use, distribution, and transport of hazardous chemicals
• Catalog of Hazardous Chemicals (2015 Edition): Listed
• Rules for Classification and Labelling of Chemicals (GB 30000 series): GHS classification and labeling standards
• Safety Data Sheet for Chemical Products - Content and Order of Sections (GB/T 16483-2008): SDS preparation standard
• Provisions on the Safe Use of Chemicals in the Workplace (Ministry of Labor Decree No. 423 [1996])
• Occupational Exposure Limits for Hazardous Agents in the Workplace - Part 1: Chemical Agents (GBZ 2.1-2019)
• Technical Specification for Gas Cylinders (TSG 23-2021): Cylinder safety management
• Regulations on Road Transport of Dangerous Goods
• Work Safety Law of the People's Republic of China
• Law of the People's Republic of China on the Prevention and Control of Atmospheric Pollution (including greenhouse gas control)
• Law of the People's Republic of China on the Prevention and Control of Water Pollution (this substance is harmful to aquatic life)
• Law of the People's Republic of China on the Prevention and Control of Solid Waste Pollution
• Regulations on the Management of Ozone-Depleting Substances: Not a controlled substance (ODP = 0, no chlorine)

International regulations:

• UN GHS (Globally Harmonized System of Classification and Labelling of Chemicals): 8th revised edition
• Montreal Protocol: Not a controlled ozone-depleting substance (ODP = 0, no chlorine atoms)
• Kigali Amendment: Low-GWP substance (GWP = 9), far below control thresholds; enjoys favorable/exempt status
• EU F-Gas Regulation (EC 517/2014): Low-GWP substance; meets greenhouse gas emission reduction requirements
• EU REACH Regulation (EC 1907/2006): Registered substance
• EU CLP Regulation (EC 1272/2008): Classification, labelling and packaging regulation
• US EPA SNAP Program: Approved for various refrigeration applications (low-pressure chillers, high-temperature heat pumps, ORC)
• US OSHA HCS 2012: Hazard Communication Standard
• US DOT 49 CFR: Hazardous Materials Transportation Regulations
• ADR/RID: European Agreement concerning the International Carriage of Dangerous Goods by Road/Rail
• IMDG Code: International Maritime Dangerous Goods Code
• IATA DGR: International Air Transport Association Dangerous Goods Regulations

15.2 Chemical safety assessment

Chemical Safety Assessment has not been carried out for this substance in the context of this SDS. Users should conduct their own assessment based on specific use conditions.

16.1 References

• NIOSH Pocket Guide to Chemical Hazards
• NOAA CAMEO Chemicals Database
• PubChem Compound Database
• ASHRAE Handbook - Refrigeration Systems and Applications
• ASHRAE Standard 34 - Designation and Safety Classification of Refrigerants
• GB/T 16483-2008 (Content and order of sections in safety data sheet for chemical products)
• GB 30000 series (Rules for classification and labelling of chemicals)
• United Nations GHS (Globally Harmonized System of Classification and Labelling of Chemicals), 8th revised edition

16.2 Abbreviations

16.3 Disclaimer

This Safety Data Sheet (SDS) has been prepared in accordance with GB/T 16483-2008 and the UN GHS standard, and is intended to provide guidance on the safe use, handling, and disposal of this product. The information contained herein is based on publicly available chemical databases, technical literature, and national standards, and is believed to be accurate and complete as of the date of issuance. However, no warranty, express or implied, is made as to the absolute accuracy, completeness, or reliability of the information. Users should verify the applicability of the information for their specific use conditions and take necessary safety precautions. The preparer assumes no legal liability for any direct or indirect damages arising from the use of this SDS. The information in this document may be updated as new research findings and regulatory changes become available; periodic review of the latest version is recommended.